California NanoSystems Institute
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November 29, 2011

Limor Fix
Intel Labs, Pittsburgh
Industry and Academia Collaboration - revised
Abstract: The computing landscape is changing fast both that the system level with Internet of Things (IOT) and Cloud Computing, as well as, in the user experience level with sensors and social computing. Moreover, the capacity of silicon manufacturing continuous to grow and the demand for it is just as strong. In 2010, a total of 10 Billion transistors were shipped per person on earth. To fuel the growing demand for transistors and to accelerate these changes in the computing landscape, Intel continues to develop novel models for collaboration among industry and academia. In her talk, Limor will cover the research agenda of current Intel’s collaboration with universities and an overview of Intel Science and Technology Centers (ISTCs) and Intel’s Academic Research Office (ARO).

BIO: Currently Limor is co-managing the Intel Pittsburgh Lab as the Associate Director of the Lab. Limor is also an Intel Senior Principal Engineer and she has a PhD in Computer Science from the Technion, Israel,1992. After graduation, Limor conducted post-doc research in Cornell University and in 1994 she joined Intel in Israel. For 10 years Limor led a major change in Intel's validation technology and methodology. She developed innovative formal verification tools and methodology that have been widely adopted by Intel's design teams. Limor has published more than 30 papers, and she was invited to many technical program committees of leading international conferences. In the last seven years, Limor served on the executive committee of the Design Automation Conference (DAC), the leading conference for design tools with 10,000 participants and 250 companies demo suites. In 2008, Limor served as the general chair of DAC.

Limor's research interests include formal specification languages, Limor has led the development of the ForSpec formal specification language that had been donated by Intel to Accellera/IEEE and had a major impact in the IEEE-1850 standard. In addition, Limor's research also include BDD's, SAT solvers, and model checking of both hardware and distributed software. In particular, Limor has led the research and development of Intel's three generations of advanced formal verification systems, Forecast, Thunder and Foresight.

November 15, 2011

Emilio Mendez
Director Center for Functional Nanomaterials, Brookhaven National Laboratory

Streaming Video
Nanotechnology and the Energy Challenge
Abstract: Since 1973 -- the year of the first major oil crisis -- the world's energy consumption has doubled, but its portion of fossil fuels has barely changed. In 2008, 81% of the energy used still came from a combination of oil, coal, and natural gas. This large dependence on fossil fuels poses a triple challenge: the earth¡¦s reserves are limited; their uneven distribution creates geopolitical problems; and, most urgently, fossil-fuel burning is the main source of greenhouse gases that affect climate change. The answer to this challenge goes from reducing energy consumption and increasing efficiency to developing economical alternative sources. Thus, a complete response to this global problem needs to be multi-faceted, from technology innovation to economics and public policy and education.

In this talk, I will focus on the role that nanotechnology can play in addressing the energy challenge. In particular, I will concentrate on the research being conducted at the Center for Functional Nanomaterials (CFN) on novel materials and structures for catalysis, photovoltaics, and energy storage, and on the state-of-the-art facilities that make that research possible.

The CFN is one of the five Nanoscale Science Research Centers (NSRCs), distributed across the US and created by the Department of Energy to serve as hubs of nanoscience research with advanced facilities open to the scientific and technological communities. The NSRCs are an offspring of the National Nanotechnology Initiative, launched by the US government in 2000 to capitalize on the enormous potential that nanoscience and nanotechnology offer to address major societal problems.

BIO: After earning his undergraduate degree from the University of Madrid, Spain, Mendez came to the U.S. to continue his education in physics, earning a Ph.D. from the Massachusetts Institute of Technology in 1979. He then took a postdoctoral position at the IBM T. J. Watson Research Center in Yorktown Heights, New York, where he became a research staff member and eventually a member of the strategic planning group and a line manager. He joined Stony Brook University in 1995 as a physics professor, and in 2004 he became Director of the Undergraduate Program in the Department of Physics and Astronomy.

Mendez¡¦s research at IBM involved finding ways to make faster transistors and computer chips, as well as more efficient lasers. Currently, he is studying, among other materials, carbon nanotubes, cylindrical carbon molecules with novel properties that may enhance future electronic and optical devices. A Fellow of the American Physical Society, Mendez has received several awards for his significant scientific contributions, including the 1998 Prince of Asturias Prize and the 2000 Fujitsu Quantum Device International Award.

Emilio Mendez is Director of the Center for Functional Nanomaterials (CFN) at Brookhaven National Laboratory since November 2006. The CFN is one of the five user-oriented Nanoscale Science Research Centers created by the Department of Energy (DOE) to elucidate and exploit the unique properties of materials and processes at the nanoscale in addressing society's technical challenges.

The CFN has a two-fold mission: to advance the science of nanomaterials in energy-related areas, and to be an open facility and intellectual hub for nanoscience for the scientific community. The CFN's cornerstone is a unique array of state-of-the-art instruments and a dedicated endstation at the National Synchrotron Light Source (NSLS), all operated and supervised by an outstanding CFN's technical and scientific staff, who develop and implement the CFN's scientific plan and work with external users, assisting them or/and collaborating with them in pioneering nanoscience research.

November 08, 2011

Jan Van Hest
Institute for Molecules and Materials, Radboud University Groenenboom

Streaming Video
Polymer vesicles as nanoreactors and nano-engines
Abstract: Compartmentalization is one of the approaches cells adopt to enable control over (bio)chemical processes, as is illustrated by the occurrence of organelles. In this lecture two approaches will be discussed in which polymer vesicles, or polymersomes, are used for compartmentalisation to construct catalytic devices. To mimic organelles, we have developed polymersomes, which have a robust, yet semi-permeable membrane. When multiple enzymes are encapsulated inside these polymersomes, they function as biocatalytic cascade nanoreactors. After surface modification with cell penetrating peptides, these nanocontainers are taken up by cells, where they act as artificial organelles.

A different method of compartmentalization is realized using non-permeable polymersomes. After self-assembly in a mixture of organic solvent and water, these solvent-swollen polymersomes are dialyzed in the presence of platinum nanoparticles. Due to the preferred diffusion of organic solvent out of the capsules, the polymersomes experience an osmotic pressure difference and become indented, thereby encapsulating Pt nanoparticles in the newly formed nanocavities. The catalytic nanoparticles produce oxygen gas, which propels the polymersomes and turns them into nano-rockets.

BIO: Jan. C. M. van Hest conducted his doctoral research on molecular architectures based on dendrimers at Eindhoven University of Technology under supervision of Prof. Bert Meijer, for which the Ph.D. title was granted in 1996. For this research he was awarded the first prize of the DSM science and technology award (1996) and the SNS bank award of best PhD thesis in the category Technical Fundamental Research of the academic year 1995-1996 of Eindhoven University of Technology. As a postdoctoral researcher he investigated the possibilities of protein engineering for the preparation of materials under supervision of Prof. David Tirrell, at the University of Massachusetts in Amherst. In 1997 he then joined the chemical company DSM, where he worked as research scientist and later on as group leader on the development of innovative material concepts. In 2000 he was appointed as a full professor at the Radboud University Nijmegen to set up a new group in bio-organic chemistry. His current research efforts are aimed at developing bio-inspired materials and processes in order to combine the functionality of biological systems with the flexibility and robustness of synthetic structures, using a variety of synthetic techniques, such as protein engineering, peptide synthesis and controlled polymerization methods. Jan van Hest was a member of The Young Academy of the Royal Netherlands Academy of Arts and Sciences from 2005-2010 and vice dean of research of the Faculty of Science (2006-2010). In 2010 he was awarded a VICI grant for his research on artificial organelles. He is a member of the executive board of ACTS (national program of the Dutch Science Foundation on sustainable chemical technology) and initiated the national programs Process on a Chip which involves microreactor technology, and the Dutch research initiative on Chemical Biology. He is a member of the editorial board of Polymer Chemistry, and advisory board member of the Journal of Materials Chemistry, Biomacromolecules, Macromolecular Bioscience and Chemical Science, and a fellow of the RSC. He has published around 150 papers.

October 04, 2011

Adah Almutairi, PhD
Skaggs School of Pharmacy and Pharmaceutical Sciences, Department of NanoEngineering and the Materials Science and Engineering Program School: University of California San Diego

Streaming Video
The Art of Falling Apart: Exploiting Nanomaterial Disassembly for Medicine and Pharmacy
Abstract: Research in nanotechnology over the last two decades has enabled scientists and engineers to build constructs of shapes, sizes and properties previously unattainable. These efforts have been rewarded with numerous Nobel Prizes. Now is the time to also focus on controlled disassembly of nanomaterial constructs to access properties and enable technologies useful in overcoming medical and pharmaceutical challenges. This presentation will cover two new classes of materials developed. Their usefulness to a number of medical challenges such as gene delivery and inflammatory diseases will be highlighted.

BIO: Prof. Adah Almutairi moved to Los Angeles in 1997 to attend Occidental College where she was awarded the Rodna Nye Scholarship. After receiving an Advanced Bachelor in Chemistry, Prof. Almutairi was selected to receive a GAANN fellowship to continue her studies at the University of California Riverside. In 2005, she completed her PhD in Materials Chemistry and received both the UC Dissertation Award and the prestigious UC Presidential Postdoctoral Fellowship. Upon completing her postdoctoral studies at the University of California Berkeley in the laboratories of Prof. Jean Fréchet, in Chemistry and Chemical Engineering, Prof. Almutairi moved to the University of California San Diego to establish the Laboratory for Bioresponsive Materials as a Faculty of Pharmaceutical Sciences and a Faculty of the Department of NanoEngineering and a Faculty member of both Materials Science and Engineering and Biomedical Sciences. In 2009 Prof. Almutairi received the NIH Directors New Innovator Award. Adah has authored numerous publications and presented at conferences worldwide. Her research interests are in interfacing Materials Chemistry and Engineering with Biomedical Sciences for practical applications
September 27, 2011

Hilary Godwin
School of Public Health, UCLA

Streaming Video
Handling Nanomaterials Safely: Tools and Tips for Researchers

Safe Handling and Disposal of Nanomaterials in Academic Laboratories: Translating the Best Science into Best Practices

Hilary Godwin, University of California Center for Environmental Implications of Nanotechnology; Professor in the Department of Environmental Health Sciences, Institute of the Environmental and Sustainability, and California NanoSystems Institute, University of California at Los Angeles.

To ensure that nanotechnology remains a driving force for discovery and economic development for decades to come, the nanoscience and engineering community must play an active role in defining and reducing possible risks associated with this important new technology. In the University of California Center for Environmental Implications of Nanotechnology (UC CEIN), one of our primary goals is to elucidate how physicochemical properties of engineered nanomaterials influence the biological and environmental activity of nanomaterials and hence to elucidate core principles that will enable the development of next generation materials that retain their desired activities but are inherently safer by design. While our understanding of how to predict and reduce the hazards of nanomaterials is still in its infancy, there exists compelling evidence in the scientific literature to suggest that some (but certainly not all) nanomaterials pose threats to human health and the environment. Despite the current uncertainty about which new nanomaterials may be harmful to the people who make and characterize them, as mentors of emerging scientists and engineers, we all feel a moral imperative to ensure that the people we train are being adequately protected now. As scientists, we also want to ensure that policies, regulations, and practices accurately reflect the most current understanding of the hazards and mechanisms of exposure for nanomaterials. Here, I review the latest and best science in the field of Nano Occupational Health and Safety and different “guidance documents” for safe handling of nanomaterials that are currently available. In addition, I will present a “Nanotoolkit” for academic researchers who work with nanomaterials that was developed by the California Nanosafety Consortium of Higher Education as well as a comprehensive set of training materials for researchers that are being developed by the UC CEIN based on the Nanotoolkit. We anticipate that the Nanotoolkit will appeal both to researchers themselves and to Environment Health and Safety professionals in academic institutions because it that focuses on easy steps for researchers can take to lower their own risk of exposure to nanomaterials and to decrease the possibility of inadvertently releasing materials that may be hazardous into the environment.

Bio: Professor Godwin joined the UCLA faculty in 2006 and is currently a Professor in the Environmental Health Sciences Department and Associate Dean for Academic Programs in the School of Public Health. She received a B.S. in Chemistry from the University of Chicago in 1989 and a Ph.D. Physical Chemistry from Stanford University in 1994. She conducted postdoctoral research from 1994-1996 at the Johns Hopkins University School of Medicine in the Department of Biophysics and Biophysical Chemistry, where she was a National Institutes of Health postdoctoral fellow. Prior joining the faculty at UCLA, Dr. Godwin was on the faculty of the Department of Chemistry at Northwestern University, where she was an Assistant Professor (1996-2000), Associate Professor (2000-2006), Associate Chair (2003-2004), and Chair (2004-2006) of Chemistry. Dr. Godwin has received several awards, including a Camille Dreyfus Teacher-Scholar Award, an Alfred P. Sloan Research Fellowship, a National Science Foundation CAREER Award, a Burroughs Wellcome Fund Toxicology New Investigator Award, and a Camille and Henry Dreyfus New Faculty Award. She is a Howard Hughes Medical Institute Professor. Dr. Godwin's research focuses on elucidating the molecular toxicology of lead. She also works actively with community groups to prepare for and diminish the impact of climate change on public health.

Professor Godwin studies why heavy metals (such as lead) are poisonous. She is actively engaged in a number of community outreach projects, including programs to communicate science to nonscientists. She is currently developing a volunteer program, the goal of which is to prevent the spread of infectious diseases in elementary schools in Los Angeles. In addition, she is working with local and national organizations to assess the impacts of climate change on public health and how to decrease human suffering resulting from climate change.