California NanoSystems Institute
CNSI
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December 04, 2013

Aydogan Ozcan, Ph.D.
Professor, Electrical Engineering Department, UCLA
Computational Microscopy, Sensing and Diagnostics for Telemedicine and Global Health Applications
Today there are more than 6.5 billion cell-phone users in the world, and the majority of these cellphones are being used in the developing parts of the world. This massive volume of wireless phone communication brings an enormous cost-reduction to cellphones despite their sophisticated hardware and software capabilities. Utilizing this advanced state of the art of the cell phone technology towards point-of-care diagnostics and/or microscopic imaging applications can offer numerous opportunities to improve health care especially in the developing world where medical facilities and infrastructure are extremely limited or even do not exist.
Centered on this vision, in this talk I will introduce new imaging and detection architectures that can compensate in the digital domain for the lack of complexity of optical components by use of novel theories and numerical algorithms to address the immediate needs and requirements of Telemedicine for Global Health Problems. Specifically, I will present an on-chip cytometry and microscopy platform that utilizes cost-effective and compact components to enable digital recognition and 3D microscopic imaging of cells with sub-cellular resolution over a large field of view without the need for any lenses, bulky optical components or coherent sources such as lasers. This incoherent holographic imaging and diagnostic modality has orders of magnitude improved light collection efficiency and is robust to misalignments which eliminates potential imaging artifacts or the need for realignment, making it highly suitable for field use. Applications of this lensfree on-chip microscopy platform to high-throughput imaging and automated counting of whole blood cells, monitoring of HIV+ patients (through CD4 and CD8 T cell counting) and detection of waterborne parasites towards rapid screening of water quality will also be demonstrated. Further, I will discuss lensfree implementations of various other computational imaging modalities on the same platform such as pixel super-resolution imaging, lensfree on-chip tomography, holographic opto-fluidic microscopy/tomography. Finally, I will demonstrate lensfree on-chip imaging of fluorescently labeled cells over an ultra wide field of view of >8 cm2, which could be especially important for rare cell analysis (e.g., detection of circulating tumor cells), as well as for high-throughput screening of DNA/protein micro-arrays.

Biography: Dr. Aydogan Ozcan received his Ph.D. degree at Stanford University Electrical Engineering Department. After a short post-doctoral fellowship at Stanford University, he is appointed as a research faculty at Harvard Medical School, Wellman Center for Photomedicine in 2006. Dr. Ozcan joined UCLA in the summer of 2007 as an Assistant Professor, and was promoted to Associate and Full Professor ranks in 2011 and 2013, respectively. He is currently the Chancellor’s Professor at UCLA leading the Bio- and Nano-Photonics Laboratory at the Electrical Engineering and Bioengineering Departments, and is also the Associate Director of the California NanoSystems Institute (CNSI) at UCLA.
Dr. Ozcan holds 22 issued patents (all of which are licensed) and more than 15 pending patent applications for his inventions in nanoscopy, wide-field imaging, lensless imaging, nonlinear optics, fiber optics, and optical coherence tomography. Dr. Ozcan gave more than 150 invited talks and is also the author of one book, the co-author of more than 300 peer reviewed research articles in major scientific journals and conferences. In addition, Dr. Ozcan is the founder and a member of the Board of Directors of Holomic LLC.
Prof. Ozcan received several major awards including the 2011 Presidential Early Career Award for Scientists and Engineers (PECASE), which is the highest honor bestowed by the United States government on science and engineering professionals in the early stages of their independent research careers. Dr. Ozcan also received the 2013 SPIE BioPhotonics Technology Innovator Award, the 2011 Army Research Office (ARO) Young Investigator Award, 2011 SPIE Early Career Achievement Award, the 2010 NSF CAREER Award, the 2009 NIH Director’s New Innovator Award, the 2009 Office of Naval Research (ONR) Young Investigator Award, the 2009 IEEE Photonics Society Young Investigator Award and the MIT’s Technology Review TR35 Award for his seminal contributions to near-field and on-chip imaging, and telemedicine based diagnostics.
Prof. Ozcan is also the recipient of the 2013 Microscopy Today Innovation Award, 2012 Popular Science Brilliant 10 Award, 2012 National Academy of Engineering (NAE) The Grainger Foundation Frontiers of Engineering Award, 2011 Innovators Challenge Award presented by the Rockefeller Foundation and mHealth Alliance, the 2010 National Geographic Emerging Explorer Award, the 2010 Bill & Melinda Gates Foundation Grand Challenges Award, the 2010 Popular Mechanics Breakthrough Award, the 2010 Netexplorateur Award given by the Netexplorateur Observatory & Forum in France, the 2011 Regional Health Care Innovation Challenge Award given by The von Liebig Center at UCSD, the 2010 PopTech Science and Public Leaders Fellowship, the 2009 Wireless Innovation Award organized by the Vodafone Americas Foundation as well as the 2008 Okawa Foundation Award, given by the Okawa Foundation in Japan.
Prof. Ozcan was selected as one of the top 10 innovators by the U.S. Department of State, USAID, NASA, and NIKE as part of the LAUNCH: Health Forum organized in 2010. He also received the 2012 World Technology Award on Health and Medicine, which is presented by the World Technology Network in association with TIME, CNN, AAAS, Science, Technology Review, Fortune, Kurzweil and Accelerosity.
Dr. Ozcan is elected Fellow of SPIE, and is a Senior Member of IEEE and OSA, a Member of AAAS and BMES.

November 19, 2013

John Condeelis, Ph.D.
Professor, Department of Anatomy & Structural Biology, Scientific Director, Analytical Imaging Facility, Albert Einstein College of Medicine
"Imaging How a Tumor Cell Spreads Cancer" Seminar with Prof. John S. Condeelis

New developments in Multi-photon microscopy (MPM) allow the direct observation of the behavior of individual cells in vivo in real time. In mammary tumors MPM demonstrates that invasive/migratory carcinoma cells form migratory streams and intravasate when associated with macrophages.

Taking advantage of this macrophage tropism allows imaging guided collection of migratory competent macrophages and tumor cells as live cells directly from the primary tumor. Expression profiling of these co-migratory tumor cells and macrophages has led to the surprising conclusion that both cell types exhibit embryonic expression patterns.

About the Event and How to Register

This event is co-hosted by Leica Microsystems, in conjunction with the Leica Scientific Forum, West Coast-U.S. Tour.

The lecture is free. Please kindly register via email at lsf@leica-microsystems.com

Learn more at www.leica-microsystems.com/events/leica-scientific-forum/


November 05, 2013

Dean Ho, Ph.D.
Professor in the Division of Oral Biology and Medicine and Division of Advanced Prosthodontics, Biomaterials, and Hospital Dentistry, UCLA as well as Co-Director of the Jane and Jerry Weintraub Center for Reconstructive Biotechnology at the UCLA School of Dentistry
Nanodiamond-Enhanced Drug Delivery and Imaging featuring Dean Ho, Ph.D.

Nanodiamonds have emerged as promising agents for drug delivery and imaging due to their unique surface properties. Nanodiamond-anthracycline compounds have mediated major improvements to drug delivery efficacy and safety. Most recently, NDX, a nanodiamond-doxorubicin agent, markedly enhanced the pre-clinical treatment efficacy of multiple drug-resistant tumor models with no apparent myelosuppression, demonstrating potent drug binding and the absence of early drug release. Nanodiamonds bound to gadolinium have also resulted in contrast agents that are 12 times more efficient than clinical standards with among the highest ever reported per-gadolinium relaxivity values.

This lecture will highlight recent advancements in the use of nanodiamond-anthracycline complexes to address hard to treat cancers. In addition, diamond-based multimodal imaging/therapy approaches will be explored as potential clinically-relevant modalities. The combination of these pre-clinical advancements in diamond-based nanomedicine and nanodiamond surface properties serves as a foundation for a promising translational roadmap which will also be discussed.

About Dr. Dean Ho

Dr. Dean Ho, is currently a Professor in the Division of Oral Biology and Medicine and Department of Bioengineering, and Co-Director of the Weintraub Center for Reconstructive Biotechnology at the UCLA School of Dentistry. Dr. Ho was previously a faculty member at Northwestern University and joined UCLA in July 2012.

Dr. Ho’s team has developed a spectrum of nanodiamond platforms for drug delivery and imaging with improved efficacy and safety. Applications have included gene delivery, therapeutic protein release for potential wound healing use, and most notably, cancer therapy.

In the area of chemotherapy, his team developed NDX, a nanodiamond-drug complex based upon the potent interaction of the diamond surface with doxorubicin, a commonly used cancer drug in the clinic that is also highly toxic. Through the synthesis of NDX, a marked enhancement in drug efficacy and reduced toxicity were demonstrated over clinical standards. This discovery is highlighted in a recent cover article in Science Translational Medicine demonstrating the administration of NDX towards the enhanced treatment of multiple drug-resistant cancer models in mice. His research achievements have garnered news coverage on the CNN and NPR homepages, Reuters, Yahoo, Voice of America and The Chicago Tribune, among other international news outlets.


October 24, 2013

Nader Engheta, Ph.D.
H. Nedwill Ramsey Professor, Dept. of Electrical and Systems Engineering, University of Pennsylvania
Of Light, Electrons, and Metaphotonics
Abstract: As the fields of metamaterial and plasmonic nanophotonics reach certain levels of development, new directions and novel vistas appear in the horizon. Modularization, parameterization and functionalization of metamaterials may be exploited to provide new functionalities and applications stemming from such interesting platforms of metaphotonics. Indeed, the metamaterial “forms” may lead to novel “functions.” These may include “meta-systems” formed by metamaterials and metasurfaces providing wave-based mathematical operations, metamaterial-inspired optical nanocircuitry (“optical metatronics”) formed by judiciously arranging nanoparticles capable of optical processing at the nanoscale, metamaterial “bits” and “bytes” as building blocks for digitizing metamaterials, nonreciprocal metamaterials for unusual flow of photons, and nanoscale “meta-machines” as signal-processing metamaterials, to name a few. In my group we are exploring various features and characteristics of these concepts, topics, and directions in meta-optics, and we are investigating new classes of potential applications such paradigms may provide. I will present an overview of our most recent results from a sample of these topics and will discuss future directions and potentials.

Biography: Recipient of 2012 IEEE Electromagnetics Award, Nader Engheta is the H. Nedwill Ramsey Professor at the University of Pennsylvania with affiliations in the Departments of Electrical and Systems Engineering, Bioengineering, Physics and Astronomy, and Materials Science and Engineering. He received his B.S. degree from the University of Tehran, and his M.S and Ph.D. degrees from Caltech. Selected as one of the Scientific American Magazine 50 Leaders in Science and Technology in 2006 for developing the concept of optical lumped nanocircuits, he is a Guggenheim Fellow, an IEEE Third Millennium Medalist, a Fellow of IEEE, American Physical Society (APS), Optical Society of America (OSA), American Association for the Advancement of Science (AAAS), and SPIE-The International Society for Optical Engineering, and the recipient of 2013 SINA Award in Engineering, 2013 Benjamin Franklin Key Award, 2008 George H. Heilmeier Award for Excellence in Research, the Fulbright Naples Chair Award, NSF Presidential Young Investigator award, the UPS Foundation Distinguished Educator term Chair, and several teaching awards including the Christian F. and Mary R. Lindback Foundation Award, S. Reid Warren, Jr. Award and W. M. Keck Foundation Award. His current research activities span a broad range of areas including metamaterials, plasmonic optics, nanophotonics, graphene optics, imaging and sensing inspired by eyes of animal species, optical nanoengineering, fractional operators in electromagnetics, microwave and optical antennas, and engineering and physics of fields and waves. He has co-edited (with R. W. Ziolkowski) the book entitled “Metamaterials: Physics and Engineering Explorations” by Wiley-IEEE Press, 2006. He was the Chair of the Gordon Research Conference on Plasmonics in June 2012.
September 23, 2013

Richard Yamada
Professional Staff Member, Committee on Science, Space, and Technology; U.S. House of Representatives, Washington, D.C.
US Science Policy: The Art of Framing the Right Questions
In this talk, I will give a brief introduction to “practical” science policy and then discuss science policy, including the political realities surrounding the funding of federal science, from the Congressional perspective. There will also be a discussion of questions that Congress should consider when making funding decisions. These questions are particularly timely ahead of the reauthorization of the America COMPETES Act and National Nanotechnology Initiative Act. Time permitting, I hope to have an extensive question and answer period, and to use this seminar as an opportunity to listen and engage with the UCLA science and engineering community.

Richard Yamada, PhD, is currently a Professional Staff Member and Policy Advisor at the U.S. House of Representatives Committee on Science, Space and Technology. Before working for this Committee, Richard was a Research Fellow at the Center for Public Genomics, where he worked on developing quantitative frameworks for use in evaluating the role of risk in policy-related problems. During the 2011-2012 academic year, he was the AAAS-AMS Congressional Fellow, working in the office of Senator John Boozman. In that position, Richard was the chief science advisor to Senator John Boozman, Ranking Member of the Space and Science Subcommittee, 112th Congress. Prior to becoming a Fellow, Richard was an Assistant Professor of Mathematics at the University of Michigan. His scientific research has focused on developing and testing mathematical models of transcription regulation, merging experimental data, numerical algorithms and theory. He also taught courses in both pure and applied mathematics and mentored the research projects of 13 undergraduate students. Richard received his B.S. with distinction from Yale University (majoring in both physics and mathematics). He then matriculated to Cornell University where he received both his MSc and PhD in applied mathematics. His thesis focused on developing mathematical models of transcription elongation dynamics.