Andre Nel, M.B.Ch.B., Ph.D.
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Division Chief,
NanoMedicine
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Professor,
Medicine | |
Director, Center for Environmental Implications of Nanotechnology ,
California NanoSystems Institute
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Member,
California NanoSystems Institute,
NanoBiotechnology and Biomaterials
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Education: |
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Degrees:
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M.B.Ch.B., University of Stellenbosch, Capetown, R.S.A, 1975
Ph.D., University Stellenbosch, 1987
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Certifications: |
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Certifications:
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1991 American Board of Allergy and Immunology
1989 American Board of Internal Medicine
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Honors and Awards: |
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International Nanoparticle Symposium, National Institute for Environmental Studies, Tsukuba, Japan, June 2005. Title: "The Role of Oxidative Stress and Mitochondrial Damage in Mediating the Effects of DEP and Ultrafine Particles", Keynote speaker
NIH Study Section: Allergy, Immunology, and Transplantation Research Committee, NIAID 2004-2005, Chair
2007 International AAAAI Convention, John Salvaggio Memorial Lectureship and Honorary Award for outstanding service to the specialty and science of Allergy and Immunology
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Certifications: |
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Certification Type:
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NIH-funded UCLA Asthma and Allergic Disease Clinical Research, Director/PI
UC Lead Campus NanoToxicology Research Training Program, Founder/Director
2009 Foreign Member Chinese Academy of Sciences, Distinguished Professor
2008 - 2013 Center for the Environmental Impact of Nanotechnology (CEIN), Director and PI of the NSF and EPA-funded National Science Engineering Center
1998 - Peer selected inclusion, Best Doctors in America 1998-Present
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Contact Information:
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Mail Code: 173617
Los Angeles, CA 90095
UNITED STATES
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| Office Address: |
UCLA Med-NanoMedicine
10833 Le Conte Ave.
52-175 CHS
Los Angeles, CA 90095
UNITED STATES
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Work Phone Number:
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(310) 825-6011
Clinic
(310) 825-6620
Work
(310) 825-3718
Office
(310) 206-8107
Fax
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Research Interests:
Research Interests
Dr. Nel?s chief research interests are:
(i) Nanomedicine and Nanobiology, including nanomaterial therapeutic devices and the study of nanomaterial properties that lead to biocompatible and biohazardous interactions in humans and the environment;
(ii) The role of air pollutants in asthma, with particular emphasis on the role of ultrafine particle-induced oxidative stress in the generation of airway inflammation and asthma. The research is funded by personal RO1 grants from the NIH, the NIAID-funded Asthma and Immunology Disease Clinical Research Center, an EPA STAR award, a $24 million NSF award for a NSF Science Engineering Center. Dr Nel is Director of the UC Center for the Environmental Impact of Nanotechnology (CEIN), Director of the UCLA Asthma and Immunology Disease Center, Co-Director of the Southern California Particle Center, and Co-Director of the UCLA Nanomachine Center. The Nanomachine Center (four co-PI?s) develops and utilizes smart nanoparticle delivery systems that can target and control drug release at cancer and disease sites. The mission of the multi-campus UC CEIN is to develop an early warning system for nanomaterial hazards and safe design, particularly as it relates to interactions with biological systems and ecological life forms.
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Technical Research Interest:
Dr. Nel?s chief research interests are:
(i) Nanomedicine and Nanobiology, including nanomaterial therapeutic devices and the study of nanomaterial properties that lead to biocompatible and biohazardous interactions in humans and the environment;
(ii) The role of air pollutants in asthma, with particular emphasis on the role of ultrafine particle-induced oxidative stress in the generation of airway inflammation and asthma. The research is funded by personal RO1 grants from the NIH, the NIAID-funded Asthma and Immunology Disease Clinical Research Center, an EPA STAR award, a $24 million NSF award for a NSF Science Engineering Center. Dr Nel is Director of the UC Center for the Environmental Impact of Nanotechnology (CEIN), Director of the UCLA Asthma and Immunology Disease Center, Co-Director of the Southern California Particle Center, and Co-Director of the UCLA Nanomachine Center. The Nanomachine Center (four co-PI?s) develops and utilizes smart nanoparticle delivery systems that can target and control drug release at cancer and disease sites. The mission of the multi-campus UC CEIN is to develop an early warning system for nanomaterial hazards and safe design, particularly as it relates to interactions with biological systems and ecological life forms.
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Additional Information:
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Andre Nel is a tenured Professor and practicing allergist/immunologist at UCLA. He runs the Cellular Immunology Activation Laboratory in the UCLA Jonsson Comprehensive Cancer Center
Dr Nel is Director of the UC Center for the Environmental Impact of Nanotechnology (CEIN), Director of the UCLA Asthma and Immunology Disease Center, Co-Director of the Southern California Particle Center, and Co-Director of the UCLA Nanomachine Center.
Dr. Nel obtained his M.B.,Ch.B. degree in Cape Town, South Africa, and subsequently did a post-doctoral fellowship in Immunology at MUSC, which was followed by doctoral thesis on his research.
Dr. Nel is a member of the ASCI, AAAAI, AAI and the Western Association of Physicians. He served as Chair of the Allergy, Immunology, and Transplantation Research Committee, one of the NIAID Study Sections for the review of Training Grants.
Link to my PubMed publications.
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Saji George, Sijie Lin, Zhaoxia Ji, Courtney R. Thomas, LinJiang L, Mathew Mecklenburg, Huan Meng, Xiang Wang, Haiyuan Zhang, Tian Xia, J. Nathan Hohman, Shuo Lin, Jeffrey I. Zink, Paul S. Weiss, and André E. Nel, Surface Defects on Plate-Shaped Silver Nanoparticles Contribute to Its Hazard Potential in a Fish Gill Cell Line and Zebrafish Embryos, ACS Nano, 2012, 6 (5), 3745-3759.
Zhang Haiyuan, Ji Zhaoxia, Xia Tian, Meng Huan, Low-Kam Cecile, Liu Rong, Pokhrel Suman, Lin Sijie, Wang Xiang, Liao Yu-Pei, Wang Meiying, Li Linjiang, Rallo Robert, Damoiseaux Robert, Telesca Donatello, Madler Lutz, Cohen Yoram, Zink Jeffrey I, Nel Andre E, Use of Metal Oxide Nanoparticle Band Gap To Develop a Predictive Paradigm for Oxidative Stress and Acute Pulmonary Inflammation., ACS nano, 2012, 273 (5).
Xia T, Zhao Y, Sager T, George S, Pokhrel S, Li N, Schoenfeld D, Meng H, Lin S, Wang X, Wang M, Ji Z, Zink JI, Mädler L, Castranova V, Lin S, Nel AE, Decreased Dissolution of ZnO by Iron Doping Yields Nanoparticles with Reduced Toxicity in the Rodent Lung and Zebrafish Embryos, ACS Nano, 2011, 5 (2), 1223-35.
Zhang H, Xia T, Meng H, Xue M, George S, Ji Z, Wang X, Liu R, Wang M, France B, Rallo R, Damoiseaux R, Cohen Y, Bradley KA, Zink JI, Nel AE, Differential Expression of Syndecan-1 Mediates Cationic Nanoparticle Toxicity in Undifferentiated versus Differentiated Normal Human Bronchial Epithelial Cells, ACS Nano, 2011, 5 (4), 2756-69.
Thomas CR, George S, Horst AM, Ji Z, Miller RJ, Peralta-Videa JR, Xia T, Pokhrel S, Mädler L, Gardea-Torresdey JL, Holden PA, Keller AA, Lenihan HS, Nel AE, Zink JI, Nanomaterials in the environment: from materials to high-throughput screening to organisms, ACS Nano, 2011, 5 (1), 13-20.
Rallo R, France B, Liu R, Nair S, George S, Damoiseaux R, Giralt F, Nel A, Bradley K, Cohen Y, Self-Organizing Map Analysis of Toxicity-Related Cell Signaling Pathways for Metal and Metal Oxide Nanoparticles, Environ Sci Technol., 2011, Epub ahead of print.
Meng H, Xue M, Xia T, Ji Z, Tarn DY, Zink JI, Nel AE, Use of Size and a Copolymer Design Feature To Improve the Biodistribution and the Enhanced Permeability and Retention Effect of Doxorubicin-Loaded Mesoporous Silica Nanoparticles in a Murine Xenograft Tumor Model, ACS Nano, 2011, Epub ahead of print.
George S, Xia T, Rallo R, Zhao Y, Ji Z, Lin S, Wang X, Zhang H, France B, Schoenfeld D, Damoiseaux R, Liu R, Lin S, Bradley KA, Cohen Y, Nel AE, Use of a High-Throughput Screening Approach Coupled with In Vivo Zebrafish Embryo Screening To Develop Hazard Ranking for Engineered Nanomaterials, ACS Nano, 2011, 5 (3), 1805-17.
Kang Xuedong, Li Ning, Wang Meiying, Boontheung Pinmanee, Sioutas Constantinos, Harkema Jack R, Bramble Lori A, Nel Andre E, Loo Joseph A, Adjuvant effects of ambient particulate matter monitored by proteomics of bronchoalveolar lavage fluid, Proteomics, 2010, 10 (3), 520-31.
Li Ning, Harkema Jack R, Lewandowski Ryan P, Wang Meiying, Bramble Lori A, Gookin Glenn R, Ning Zhi, Kleinman Michael T, Sioutas Constantinos, Nel Andre E, Ambient ultrafine particles provide a strong adjuvant effect in the secondary immune response: implication for traffic-related asthma flares, Am J Physiol Lung Cell Mol Physiol, 2010, 299 (3), L374-83.
Meng Huan, Xue Min, Xia Tian, Zhao Yan-Li, Tamanoi Fuyuhiko, Stoddart J Fraser, Zink Jeffrey I, Nel Andre E, Autonomous in vitro anticancer drug release from mesoporous silica nanoparticles by pH-sensitive nanovalves, Journal of the American Chemical Society, 2010, 132 (36), 12690-7.
Ji Zhaoxia, Jin Xue, George Saji, Xia Tian, Meng Huan, Wang Xiang, Suarez Elizabeth, Zhang Haiyuan, Hoek Eric M V, Godwin Hilary, Nel Andre E, Zink Jeffrey I, Dispersion and stability optimization of TiO2 nanoparticles in cell culture media, Environ Sci Technol, 2010, 44 (19), 7309-14.
Meng Huan, Liong Monty, Xia Tian, Li Zongxi, Ji Zhaoxia, Zink Jeffrey I, Nel Andre E, Engineered design of mesoporous silica nanoparticles to deliver doxorubicin and P-glycoprotein siRNA to overcome drug resistance in a cancer cell line, ACS Nano, 2010, 4 (8), 4539-50.
Wang X, Xia T, Ntim SA, Ji Z, George S, Meng H, Zhang H, Castranova V, Mitra S, Nel AE, Quantitative techniques for assessing and controlling the dispersion and biological effects of multiwalled carbon nanotubes in mammalian tissue culture cells, ACS Nano., 2010, 4 (12), 7241-52.
George Saji, Pokhrel Suman, Xia Tian, Gilbert Benjamin, Ji Zhaoxia, Schowalter Marco, Rosenauer Andreas, Damoiseaux Robert, Bradley Kenneth A, Mädler Lutz, Nel Andre E, Use of a rapid cytotoxicity screening approach to engineer a safer zinc oxide nanoparticle through iron doping, ACS nano, 2010, 4 (1), 15-29.
Kovochich Michael, Espinasse Benjamin, Auffan Melanie, Hotze Ernest M, Wessel Lauren, Xia Tian, Nel Andre E, Wiesner Mark R, Comparative toxicity of C60 aggregates toward mammalian cells: role of tetrahydrofuran (THF) decomposition, Environmental science & technology, 2009, 43 (16), 6378-84.
Klichko Y, Liong M, Choi E, Angelos S, Nel AE, Stoddart JF, Tamanoi F, Zink JI., Mesostructured Silica for Optical Functionality, Nanomachines, and Drug Delivery, J Am Ceram Soc., 2009, 92 (s1), s2-s10.
Zhang, L. Wang, M. Kang, X. Boontheung, P. Li, N. Nel, A. E. Loo, J. A., Oxidative Stress and Asthma: Proteome Analysis of Chitinase-like Proteins and FIZZ1 in Lung Tissue and Bronchoalveolar Lavage Fluid, J Proteome Res, 2009, 8 (4), 1631?38.
Araujo Jesus A, Nel Andre E, Particulate matter and atherosclerosis: role of particle size, composition and oxidative stress, Particle and fibre toxicology, 2009, 6 (10), 24.
Xia Tian, Kovochich Michael, Liong Monty, Meng Huan, Kabehie Sanaz, George Saji, Zink Jeffrey I, Nel Andre E, Polyethyleneimine coating enhances the cellular uptake of mesoporous silica nanoparticles and allows safe delivery of siRNA and DNA constructs, ACS nano, 2009, 3 (10), 3273-86.
Xia, T. Li, N. Nel, A. E. , Potential Health Impact of Nanoparticles, Annu Rev Public Health, 2009, 30, 137-50.
Ning Li, Meiying Wang, Lori A. Bramble, Debra A. Schmitz, James J. Schauer, Constantinos Sioutas, Jack R. Harkema, Andre E. Nel, The Adjuvant Effect of Ambient Particulate Matter Is Closely Reflected by the Particulate Oxidant Potential, Environ Health Perspect., 2009, 117 (7), 1116-23 .
Godwin Hilary A, Chopra Kabir, Bradley Kenneth A, Cohen Yoram, Harthorn Barbara Herr, Hoek Eric M V, Holden Patricia, Keller Arturo A, Lenihan Hunter S, Nisbet Roger M, Nel Andre E, The University of California Center for the Environmental Implications of Nanotechnology, Environ Sci Technol, 2009, 43 (17), 6453-7.
Li Ning, Wang Meiying, Bramble Lori A, Schmitz Debra A, Schauer James J, Sioutas Constantinos, Harkema Jack R, Nel Andre E, The adjuvant effect of ambient particulate matter is closely reflected by the particulate oxidant potential, Environ Health Perspect, 2009, 117 (7), 1116-23.
Viera Loida, Chen Karin, Nel Andre, Lloret Maria Garcia, The impact of air pollutants as an adjuvant for allergic sensitization
and asthma., Current allergy and asthma reports, 2009, 9 (4), 327-33.
Nel AE, Mädler L, Velegol D, Xia T, Hoek EM, Somasundaran P, Klaessig F, Castranova V, Thompson M., Understanding biophysicochemical interactions at the nano-bio interface, Nature Materials, 2009, 8 (7), 543-57.
Araujo JA, Barajas B, Kleinman M, Wang X, Bennett BJ, Gong KW, Navab M, Harkema J, Sioutas C, Lusis AJ, Nel AE., Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress, Circ Res., 2008, 102 (5), 589-96.
Xia, T. Kovochich, M. Liong, M. Zink, J. I. Nel, A. E. , Cationic polystyrene nanosphere toxicity depends on cell-specific endocytic and mitochondrial injury pathways, ACS Nano, 2008, 2 ( 1), 85-96.
Ayres JG, Borm P, Cassee FR, Castranova V, Donaldson K, Ghio A, Harrison RM, Hider R, Kelly F, Kooter IM, Marano F, Maynard RL, Mudway I, Nel A, Sioutas C, Smith S, Baeza-Squiban A, Cho A, Duggan S, Froines J, Evaluating the toxicity of airborne particulate matter and nanoparticles by measuring oxidative stress potential--a workshop report and consensus statement, Inhalation Toxicology, 2008, 20 (1), 75-99.
Nicolas W.J. Schröder, Timothy R. Crother, Yoshikazu Naiki, Shuang Chen, Michelle H. Wong, Atilla Yilmaz, Anatoly Slepenkin, Danica Schulte, Randa Alsabeh, Terence M. Doherty, Ellena Peterson, Andre E. Nel, Moshe Arditi, Innate immune responses during respiratory tract infection with a bacterial pathogen induce allergic airway sensitization, Journal of Allergy and Clinical Immunology, 2008, 122 (3), 595-602.
Monty Liong, Jie Lu, Michael Kovochich, Tian Xia, Stefan G. Ruehm, Andre E. Nel, Fuyuhiko Tamanoi and Jeffrey I. Zink, Multifunctional Inorganic Nanoparticles for Imaging, Targeting, and Drug Delivery, ACS Nano, 2008, 2 (5), 889-96.
Xia T, Rome L, Nel A., Nanobiology: particles slip cell security, Nat Mater. , 2008, 7 (7), 519-20.
Kim, H. J. Barajas, B. Wang, M. Nel, A. E. , Nrf2 activation by sulforaphane restores the age-related decrease of T(H)1 immunity: role of dendritic cells, J Allergy Clin Immunol, 2008, 121 ( 5), 1255-1261 e7.
Chatila, T.A, Li, N., Garcia-Lloret, M., Kim, H-J., and Nel, A.E., T cell effector pathways in Allergic Diseases: Transcriptional Mechanisms and Therapeutic Targets, J. Allergy Clin. Immun. , 2008, 121 (4), 812-23.
Bernstein JA, Alexis N, Bacchus H, Bernstein IL, Fritz P, Horner E, Li N, Mason S, Nel A, Oullette J, Reijula K, Reponen T, Seltzer J, Smith A, Tarlo SM, The health effects of non-industrial indoor air pollution, J Allergy Clin Immunol., 2008, 121 (3), 585-591.
Li, N. Xia, T. Nel, A. E. , The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles, Free Radic Biol Med, 2008, 44 ( 9), 1689-99.
Gong KW, Zhao W, Li N, Barajas B, Kleinman M, Sioutas C, Horvath S, Lusis AJ, Nel A, Araujo JA., Air-pollutant chemicals and oxidized lipids exhibit genome-wide synergistic effects on endothelial cells, Genome Biol., 2007, 8 (7), R149.
Kim HJ, Barajas B, Chan RC, Nel AE, Glutathione depletion inhibits dendritic cell maturation and delayed-type hypersensitivity: implications for systemic disease and immunosenescence, J Allergy Clin Immunol, 2007, 119 (5), 1225-33.
Xia T, Kovochich M, Nel AE, Impairment of mitochondrial function by particulate matter (PM) and their toxic components: implications for PM-induced cardiovascular and lung disease, Front Biosci., 2007, 12, 1238-46.
Lu J, Liong M, Sherman S, Xia T, Kovochich M, Nel AE, Zink JI, Tamanoi F, Mesoporous Silica Nanoparticles for Cancer Therapy: Energy-Dependent Cellular Uptake and Delivery of Paclitaxel to Cancer Cells, Nanobiotechnology, 2007, 3 (2), 89-95.
Shi H, Xia T, Nel AE, Yeh JI, Part II: coordinated biosensors--development of enhanced nanobiosensors for biological and medical applications, Nanomedicine, 2007, 2 (5), 599-614.
Jung EJ, Avliyakulov NK, Boontheung P, Loo JA, Nel AE, Pro-oxidative DEP chemicals induce heat shock proteins and an unfolding protein response in a bronchial epithelial cell line as determined by DIGE analysis, Proteomics, 2007, 7 (21), 3906-18.
Xia T, Kovochich M, Brant J, Hotze M, Sempf J, Oberley T, Sioutas C, Yeh JI, Wiesner MR and Nel AE, Comparison of the Abilities of Ambient and Manufactured Nanoparticles to Induce Cellular Toxicity According to an Oxidative Stress Paradigm, Nano Letters, 2006, 6 (8), 1794-1807.
Chan RC, Wang M, Li N, Yanagawa Y, Onoé K, Lee JJ, Nel AE, Pro-oxidative diesel exhaust particle chemicals inhibit LPS-induced dendritic cell responses involved in T-helper differentiation, J Allergy Clin Immunol, 2006, 118 (2), 455-65.
Xia T, Kovochich M, Nel A, The role of reactive oxygen species and oxidative stress in mediating particulate matter injury, Clin Occup Environ Med. , 2006, 5 (4), 817-36.
Nel A, Xia T, Maedler L, Li N, Toxic Potential of Materials at the Nanolevel, Science, 2006, 311 (5761), 622-627.
Phalen RF, Oldham MJ, Nel AE, Tracheobronchial particle dose considerations for in vitro toxicology studies, Toxicol Sci., 2006, 92 (1), 126-32.
Nel A , Air Pollution-Related Illness: Biomolecular Effects of Particles, Science, 2005, 308 (5273), 804-6.
Xiao GG, Nel AE, Loo JA, Nitrotyrosine-modified proteins and oxidative stress induced by diesel exhaust particles, Electrophoresis, 2005, 26 (1), 280-92.
Wang M, Xiao GC, Li N, Xie Y, Loo JA and Nel AE, Phosphorproteome and cytokine array analysis show MAP kinases mediate inflammation by pro-oxidative diesel exhaust particle chemicals, Electrophoresis, 2005, 26 (11), 2092-2108.
Kim HJ, Nel AE, The role of phase II antioxidant enzymes in protecting memory T cells from spontaneous apoptosis in young and old mice, Journal of Immunology, 2005, 175 (5), 2948-59.
Li N, Alam J, Venkatesan MI, Eiguren-Fernandez A, Schmitz D, Di Stefano E, Slaughter N, Killeen E, Wang X, Huang A, Wang M, Miguel AH, Cho A, Sioutas C, Nel AE, Nrf2 is a key transcription factor that regulates antioxidant defense in macrophages and epithelial cells: protecting against the proinflammatory and oxidizing effects of diesel exhaust chemicals, Journal of Immunology, 2004, 173 (5), 3467-81.
Xia T, Korge P, Weiss JN, Li N, Venkatesen I, Sioutas C and Nel A, Quinones and Aromatic Chemical Compounds in Particulate Matter (PM) Induce Mitochondrial Dysfunction: Implications for PM-induced Oxidative Stress and Toxicity, Environ Health Perspectives, 2004, 112 (14), 1347-1358.
Li N, Hao M, Phalen RF, Hinds WC, Nel AE, Particulate air pollutants and asthma. A paradigm for the role of oxidative stress in PM-induced adverse health effects, Clinical Immunology, 2003, 109 (3), 250-65.
Xiao GG, Wang M, Li N, Loo JA, Nel AE, Use of proteomics to demonstrate a hierarchical oxidative stress response to diesel exhaust particle chemicals in a macrophage cell line, The Journal of Biological Chemistry, 2003, 278 (50), 50781-90.
Yuan J, Bae D, Cantrell D, Nel AE, Rozengurt E., Protein kinase D is a downstream target of protein kinase Ctheta, Biochem Biophys Res Commun, 2002, 291 (3), 444-52.
Nel AE, T-cell activation through the antigen receptor. Part 1: signaling components, signaling pathways, and signal integration at the T-cell antigen receptor synapse, J Allergy Clin Immunol. , 2002, 109 (5), 758-70.
Whitekus MJ, Li N, Zhang M, Wang M, Horwitz MA, Nelson SK, Horwitz LD, Brechun N, Diaz-Sanchez D, Nel AE, Thiol antioxidants inhibit the adjuvant effects of aerosolized diesel exhaust particles in a murine model for ovalbumin sensitization, J Immunol, 2002, 168 (5), 2560-7.
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